ARG67253
anti-OVOL2 antibody [SQab30371]
anti-OVOL2 antibody [SQab30371] for IHC-Formalin-fixed paraffin-embedded sections and Human
. [Uniprot]
Overview
| Product Description | Rabbit Monoclonal antibody [SQab30371] recognizes OVOL2. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30371 |
| Isotype | IgG |
| Target Name | OVOL2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to Human OVOL2. |
| Conjugation | Un-conjugated |
| Alternate Names | OVOL2; Ovo Like Zinc Finger 2; Zinc Finger Protein 339; ZNF339; CHED; Corneal Endothelial Dystrophy 1 (Autosomal Dominant); Transcription Factor Ovo-Like 2; BA504H3.3; HOVO2; CHED1; Ovo-Like 2 (Drosophila); EUROIMAGE566589; CHED2; PPCD1; HOvo2 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | OVOL2 |
| Gene Full Name | Ovo Like Zinc Finger 2 |
| Background | This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016] |
| Function | Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity. [Uniprot] |
| Cellular Localization | Nucleus. [Uniprot] |
| Highlight | . [Uniprot] |
| Research Area | . [Uniprot] |
| Calculated MW | 30 kDa |
| PTM | Phosphoprotein. [Uniprot] |
Images (2) Click the Picture to Zoom In
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ARG67253 anti-OVOL2 antibody [SQab30371] IHC-P image
Immunohistochemistry: Human Colon cancer stained with ARG67253 anti-OVOL2 antibody [SQab30371] at 1:100 dilution.
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ARG67253 anti-OVOL2 antibody [SQab30371] IHC-P image
Immunohistochemistry: Human Colon cancer stained with ARG67253 anti-OVOL2 antibody [SQab30371] at 1:100 dilution.
