anti-Osteocalcin antibody [2H9]

anti-Osteocalcin antibody [2H9] for ELISA and Human

Developmental Biology antibody; Signaling Transduction antibody


Product Description Mouse Monoclonal antibody [2H9] recognizes Osteocalcin
Tested Reactivity Hu
Predict Reactivity Bov, Rat, Pig
Species Does Not React With Ms
Tested Application ELISA
Specificity This antibody cross-reacts with bovine, rat and pig Osteocalcin and is not cross-reacting with mouse Osteocalcin.
Host Mouse
Clonality Monoclonal
Clone 2H9
Isotype IgG2a
Target Name Osteocalcin
Antigen Species Human
Immunogen Recombinant Human Osteocalcin with glutathione S-transferase
Conjugation Un-conjugated
Alternate Names OCN; Gamma-carboxyglutamic acid-containing protein; Osteocalcin; OC; Bone Gla protein; BGP

Application Instructions

Application Note Recommended pairs for sandwich immunoassay (capture-detection): ARG10528 - ARG10529 (detects the large NH2- terminal fragment and intact hOC)


Form Liquid
Purification Purification with Protein A.
Buffer PBS (pH 7.4) and 0.09 % Sodium azide
Preservative 0.09 % Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 632 Human BGLAP

Swiss-port # P02818 Human Osteocalcin

Gene Symbol BGLAP
Gene Full Name bone gamma-carboxyglutamate (gla) protein
Background This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
Function Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. [UniProt]
Highlight Related Antibody Duos and Panels:
ARG30290 Osteocalcin ELISA Antibody Duo
Related products:
Osteocalcin antibodies; Osteocalcin ELISA Kits; Osteocalcin Duos / Panels; Anti-Mouse IgG secondary antibodies;
Research Area Developmental Biology antibody; Signaling Transduction antibody
Calculated MW 11 kDa
PTM Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.