ARG10529

anti-Osteocalcin antibody [6F9]

anti-Osteocalcin antibody [6F9] for ELISA and Human

Developmental Biology antibody; Signaling Transduction antibody

Overview

Product Description Mouse Monoclonal antibody [6F9] recognizes Osteocalcin
Tested Reactivity Hu
Species Does Not React With Ms, Rat, Bov, Pig, Rb
Tested Application ELISA
Specificity This antibody is not cross-reacting with bovine, rat, mouse, rabbit or pig Osteocalcin.
Host Mouse
Clonality Monoclonal
Clone 6F9
Isotype IgG1
Target Name Osteocalcin
Antigen Species Human
Immunogen Recombinant Human Osteocalcin with glutathione S-transferase
Conjugation Un-conjugated
Full Name bone gamma-carboxyglutamate (gla) protein
Alternate Names OCN; Gamma-carboxyglutamic acid-containing protein; Osteocalcin; OC; Bone Gla protein; BGP

Application Instructions

Application Note Recommended pairs for sandwich immunoassay (capture-detection): ARG10528 - ARG10529 (detects the large NH2- terminal fragment and intact hOC)

Properties

Form Liquid
Purification Purification with Protein A.
Buffer PBS (pH 7.4) and 0.09 % Sodium azide
Preservative 0.09 % Sodium azide
Concentration 2 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 632 Human BGLAP

Swiss-port # P02818 Human Osteocalcin

Gene Symbol BGLAP
Gene Full Name bone gamma-carboxyglutamate (gla) protein
Background This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
Function Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. [UniProt]
Research Area Developmental Biology antibody; Signaling Transduction antibody
PTM Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.