anti-P Cadherin antibody [NCC-CAD-299]

anti-P Cadherin antibody [NCC-CAD-299] for Western blot,Immunohistochemistry and Human

Neuroscience antibody; Signaling Transduction antibody


Product Description Mouse Monoclonal antibody [NCC-CAD-299] recognizes P Cadherin
Tested Reactivity Hu
Tested Application IHC, WB
Specificity This antibody specifically reacts withhuman P-Cadherin, and inhibits PCadherindependent cell-cell contact
Host Mouse
Clonality Monoclonal
Clone NCC-CAD-299
Isotype IgG1
Target Name P Cadherin
Antigen Species Human
Immunogen Human epidermal carcinomacell line A431.
Conjugation Un-conjugated
Alternate Names PCAD; Cadherin-3; P-cadherin; HJMD; Placental cadherin; CDHP

Application Instructions

Application Note Western blot: 5 - 10 ug/ml, nonreducing and non - heating conditions.
Immunohistochemistry: 5 - 10 ug/ml,
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Buffer 10 mM PBS (pH 7.4) and 1% BSA
Stabilizer 1% BSA
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 1001 Human CDH3

Swiss-port # P22223 Human Cadherin-3

Gene Symbol CDH3
Gene Full Name cadherin 3, type 1, P-cadherin (placental)
Background This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. [UniProt]
Research Area Neuroscience antibody; Signaling Transduction antibody
Calculated MW 91 kDa

Clone References

Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells.

Inhib / Human

Chanson L et al.
Proc Natl Acad Sci U S A.,  (2011)