ARG10431

anti-PAPP A antibody [5H9]

anti-PAPP A antibody [5H9] for ELISA,Western blot and Human

Overview

Product Description Mouse Monoclonal antibody [5H9] recognizes PAPP A
Tested Reactivity Hu
Tested Application ELISA, WB
Specificity This antibody is specific to proMBP subunit.
Host Mouse
Clonality Monoclonal
Clone 5H9
Isotype IgG2b
Target Name PAPP A
Antigen Species Human
Immunogen Human PAPP A antigen purified from placental blood (heterotetrameric complex, consisting of PAPP A subunits and proMBP subunits).
Conjugation Un-conjugated
Full Name pregnancy-associated plasma protein A, pappalysin 1
Alternate Names DIPLA1; Pappalysin-1; Insulin-like growth factor-dependent IGF-binding protein 4 protease; PAPPA1; IGFBP-4ase; Pregnancy-associated plasma protein A; PAPA; IGF-dependent IGFBP-4 protease; EC 3.4.24.79; PAPP-A; ASBABP2

Application Instructions

Application Suggestion
Tested Application
ELISAAssay-dependent
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein A.
Buffer PBS (pH 7.4) and 0.1% Sodium azide
Preservative 0.1% Sodium azide
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 5069 Human PAPPA

Swiss-port # Q13219 Human Pappalysin-1

Gene Symbol PAPPA
Gene Full Name pregnancy-associated plasma protein A, pappalysin 1
Background This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]
Function Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. [UniProt]
PTM There appear to be no free sulfhydryl groups.

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  • ARG10431 anti-PAPP A antibody [5H9] WB image

    Western blot: proMBP subunit of Human total PAPP-A stained with ARG10431 anti-PAPP A antibody [5H9].