ARG10817

anti-PDE11A phospho (Ser117 / Ser124) antibody

anti-PDE11A phospho (Ser117 / Ser124) antibody for ELISA,Immunoprecipitation,Western blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes PDE11A phospho (Ser117 / Ser124)
Tested Reactivity Hu, Ms, Rat
Tested Application ELISA, IP, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name PDE11A
Species Human
Immunogen Synthetic peptide taken within aa. 100-150 from PDE11A protein. Phosphorylated at Ser117 and Ser124.
Conjugation Un-conjugated
Full Name phosphodiesterase 11A
Alternate Names EC 3.1.4.35; PPNAD2; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A; EC 3.1.4.53

Application Instructions

Application Suggestion
Tested Application Dilution
ELISA1:10000
IP1:250
WB1:500
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 105 kDa
Observed Size ~ 105 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 30% Glycerol and 0.5% BSA
Concentration 0.5 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 140928 Rat PDE11A

GeneID: 241489 Mouse PDE11A

GeneID: 50940 Human PDE11A

Gene Symbol PDE11A
Gene Full Name phosphodiesterase 11A
Background The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. [UniProt]

Images (2) Click the Picture to Zoom In

  • ARG10817 anti-PDE11A phospho (Ser117 / Ser124) antibody WB image

    Western blot: GFP-PDE11A variants stained with ARG10817 anti-PDE11A phospho (Ser117 / Ser124) antibody.

  • ARG10817 anti-PDE11A phospho (Ser117 / Ser124) antibody WB image

    Western blot: 1) Rat testis, and 2) Rat liver (Negative control) stained with ARG10817 anti-PDE11A phospho (Ser117 / Ser124) antibody at 1:250 dilution, 1 hour incubation at RT.