ARG10793

anti-PDE1C antibody

anti-PDE1C antibody for Confocal microscopy (Confocal),ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot,Dot blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes PDE1C
Tested Reactivity Hu, Ms, Rat
Tested Application Confocal, Dot, ELISA, ICC/IF, IHC-P, IP, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name PDE1C
Species Human
Immunogen Synthetic peptide from Human PDE1C.
Conjugation Un-conjugated
Full Name phosphodiesterase 1C, calmodulin-dependent 70kDa
Alternate Names Hcam3; cam-PDE 1C; EC 3.1.4.17; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; Cam-PDE 1C; hCam-3

Application Instructions

Application Suggestion
Tested Application Dilution
Confocal1:40 - 1:100
Dot1:10000
ELISA1:10000
ICC/IF1:40 - 1:100
IHC-P1:40 - 1:100
IP1:200
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW PDE1C1: 76 kDa
PDE1C2: 70 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 30% Glycerol and 0.5% BSA
Concentration 0.5 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 18575 Mouse PDE1C

GeneID: 5137 Human PDE1C

GeneID: 81742 Rat PDE1C

Gene Symbol PDE1C
Gene Full Name phosphodiesterase 1C, calmodulin-dependent 70kDa
Background Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).[supplied by OMIM, Oct 2009]
Function Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. [UniProt]

Images (3) Click the Picture to Zoom In

  • ARG10793 anti-PDE1C antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human ovarian medulla tissue stained with ARG10793 anti-PDE1C antibody at 1:1500 dilution.

  • ARG10793 anti-PDE1C antibody WB image

    Western blot: Recombinant PDE1C2 and PDE1C1 protein stained with ARG10793 anti-PDE1C antibody at 1:500 dilution.

  • ARG10793 anti-PDE1C antibody WB image

    Western blot: 50 µg of Rat brain on SDS-PAGE stained with ARG10793 anti-PDE1C antibody at 1:250 dilution.