ARG10806

anti-PDE6A antibody

anti-PDE6A antibody for Confocal microscopy (Confocal),ELISA,ICC/IF,Immunohistochemistry,Immunoprecipitation,Western blot,Dot blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes PDE6A
Tested Reactivity Hu, Ms, Rat
Tested Application Confocal, Dot, ELISA, ICC/IF, IHC, IP, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name PDE6A
Species Human
Immunogen Synthetic cyclic peptide common to all PDE6 alpha variants.
Conjugation Un-conjugated
Full Name phosphodiesterase 6A, cGMP-specific, rod, alpha
Alternate Names RP43; CGPR-A; PDEA; GMP-PDE alpha; PDE V-B1; EC 3.1.4.35; Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Application Instructions

Application Suggestion
Tested Application Dilution
Confocal1:250
Dot1:10000
ELISA1:10000
ICC/IF1:250
IHC1:250
IP1:250
WB1:500
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 100 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 30% Glycerol and 0.5% BSA
Concentration 0.5 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 110855 Mouse PDE6C

GeneID: 5146 Human PDE6C

Swiss-port # P51160 Human Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Swiss-port # Q91ZQ1 Mouse Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Gene Symbol PDE6A
Gene Full Name phosphodiesterase 6A, cGMP-specific, rod, alpha
Background This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]
Function This protein participates in processes of transmission and amplification of the visual signal. [UniProt]

Images (1) Click the Picture to Zoom In

  • ARG10806 anti-PDE6A antibody IHC image

    Immunohistochemistry: Lung tissue stained with ARG10806 anti-PDE6A antibody.