ARG47216
anti-PDE6C antibody
anti-PDE6C antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes PDE6C |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Target Name | PDE6C |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human PDE6C. |
| Conjugation | Un-conjugated |
| Alternate Names | PDE6C; Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; PDEA2; cGMP phosphodiesterase 6C |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A |
| Buffer | PBS, 0.09% Sodium azide, 50% Glycerol and 0.5% BSA |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P51160 Human Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
|---|---|
| Gene Symbol | PDE6C |
| Gene Full Name | phosphodiesterase 6C |
| Background | This gene encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. Mutations in this gene are associated with cone dystrophy type 4 (COD4). [provided by RefSeq, Mar 2010] |
| Function | Catalytic alpha subunit of the cone-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP as part of the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic alpha subunits (PDE6C) and two inhibitory gamma subunits (PDE6H). [UniProt] |
| Cellular Localization | Membrane. [UniProt] |
| Calculated MW | 99 kDa |
| PTM | Lipoprotein; Methylation. [UniProt] |
