ARG47217
anti-PDE6G antibody
anti-PDE6G antibody for Western blot and Mouse
Overview
| Product Description | Mouse Monoclonal antibody recognizes PDE6G |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Target Name | PDE6G |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human PDE6G. |
| Conjugation | Un-conjugated |
| Alternate Names | PDE6G; Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma; PDEG |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A |
| Buffer | PBS, 0.09% Sodium azide, 50% Glycerol and 0.5% BSA |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P09174 Mouse Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subuni |
|---|---|
| Gene Symbol | PDE6G |
| Gene Full Name | phosphodiesterase 6G |
| Background | This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009] |
| Function | Inhibitory gamma subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits. Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification. [UniProt] |
| Cellular Localization | Cell projection. [UniProt] |
| Calculated MW | 10 kDa |
| PTM | Acetylation. [UniProt] |
