ARG47220
anti-PDZRN3 antibody
anti-PDZRN3 antibody for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes PDZRN3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Target Name | PDZRN3 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human PDZRN3. |
| Conjugation | Un-conjugated |
| Alternate Names | PDZRN3; E3 ubiquitin-protein ligase PDZRN3; KIAA1095; LNX3; SEMCAP3; Ligand of Numb protein X 3; PDZ domain-containing RING finger protein 3; RING-type E3 ubiquitin transferase PDZRN3; Semaphorin cytoplasmic domain-associated protein 3; Protein SEMACAP3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A |
| Buffer | PBS, 0.09% Sodium azide, 50% Glycerol and 0.5% BSA |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9UPQ7 Human E3 ubiquitin-protein ligase PDZRN3 |
|---|---|
| Gene Symbol | PDZRN3 |
| Gene Full Name | PDZ domain containing ring finger 3 |
| Background | This gene encodes a member of the LNX (Ligand of Numb Protein-X) family of RING-type ubiquitin E3 ligases. This protein may function in vascular morphogenesis and the differentiation of adipocytes, osteoblasts and myoblasts. This protein may be targeted for degradation by the human papilloma virus E6 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| Function | E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. [UniProt] |
| Cellular Localization | Cytoplasm. [UniProt] |
| Calculated MW | 120 kDa |
| PTM | Phosphoprotein; Ubl conjugation. [UniProt] |
