anti-PGCB antibody for Confocal microscopy (Confocal),ELISA,ICC/IF,Immunohistochemistry,Immunoprecipitation,Western blot,Dot blot and Human,Mouse,Rat
|Product Description||Rabbit Polyclonal antibody recognizes PGCB|
|Tested Reactivity||Hu, Ms, Rat|
|Tested Application||Confocal, Dot, ELISA, ICC/IF, IHC, IP, WB|
|Immunogen||Synthetic peptide around the C-terminus of PGCB protein.|
|Alternate Names||ANPRB; AMDM; GUCY2B; ECDM; Atrial natriuretic peptide receptor 2; NPR-B; SNSK; NPRBi; Guanylate cyclase B; NPRB; ANPb; Atrial natriuretic peptide receptor type B; GUC2B; EC 188.8.131.52; GC-B; ANPR-B; ANP-B|
|Application Note||* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.|
|Buffer||Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA.|
|Preservative||0.02% Sodium azide|
|Stabilizer||30% Glycerol and 0.5% BSA|
|Storage Instruction||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
|Gene Full Name||natriuretic peptide receptor 2|
|Background||This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]|
|Function||Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. [UniProt]|
|Calculated MW||117 kDa|
|PTM||Phosphorylated (PubMed:26980729). Phosphorylation of the protein kinase-like domain is required for full activation by CNP (By similarity).
Images (2) Click the Picture to Zoom In
ARG10814 anti-PGCB antibody IHC image
Immunohistochemistry: Thin section of Mouse nose tissue stained with ARG10814 anti-PGCB antibody (red). Green: Grueneberg ganglion neurons. Blue: Nuclei. Staining is found on blood vessel walls.
ARG10814 anti-PGCB antibody WB image
Western blot: Recombinant PGCB protein stained with ARG10814 anti-PGCB antibody at 1:500 dilution.