ARG10814

anti-PGCB antibody

anti-PGCB antibody for Confocal microscopy (Confocal),ELISA,ICC/IF,Immunohistochemistry,Immunoprecipitation,Western blot,Dot blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes PGCB
Tested Reactivity Hu, Ms, Rat
Tested Application Confocal, Dot, ELISA, ICC/IF, IHC, IP, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name PGCB
Species Human
Immunogen Synthetic peptide around the C-terminus of PGCB protein.
Conjugation Un-conjugated
Full Name natriuretic peptide receptor 2
Alternate Names ANPRB; AMDM; GUCY2B; ECDM; Atrial natriuretic peptide receptor 2; NPR-B; SNSK; NPRBi; Guanylate cyclase B; NPRB; ANPb; Atrial natriuretic peptide receptor type B; GUC2B; EC 4.6.1.2; GC-B; ANPR-B; ANP-B

Application Instructions

Application Suggestion
Tested Application Dilution
Confocal1:200
Dot1:10000
ELISA1:10000
ICC/IF1:50 - 1:200
IHC1:200
IP1:200
WB1:500
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 117 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 30% Glycerol and 0.5% BSA
Concentration 0.5 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 116564 Rat NPR2

GeneID: 230103 Mouse NPR2

GeneID: 4882 Human NPR2

Gene Symbol NPR2
Gene Full Name natriuretic peptide receptor 2
Background This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
Function Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. [UniProt]
PTM Phosphorylated (PubMed:26980729). Phosphorylation of the protein kinase-like domain is required for full activation by CNP (By similarity).
Glycosylated.

Images (2) Click the Picture to Zoom In

  • ARG10814 anti-PGCB antibody IHC image

    Immunohistochemistry: Thin section of Mouse nose tissue stained with ARG10814 anti-PGCB antibody (red). Green: Grueneberg ganglion neurons. Blue: Nuclei. Staining is found on blood vessel walls.

  • ARG10814 anti-PGCB antibody WB image

    Western blot: Recombinant PGCB protein stained with ARG10814 anti-PGCB antibody at 1:500 dilution.