ARG46725
anti-PITX2 / RGS antibody
anti-PITX2 / RGS antibody for Western blot,Flow cytometry and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PITX2 / RGS |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PITX2 / RGS |
| Antigen Species | Human |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of PITX2/RGS |
| Conjugation | Un-conjugated |
| Alternate Names | PITX2; Paired Like Homeodomain 2; ARP1; Paired-Like Homeodomain Transcription Factor 2; Otlx2; RIEG1; IGDS; Brx1; RIEG; RGS; RS; ALL1-Responsive Protein ARP1; Homeobox Protein PITX2; Pituitary Homeobox 2; Solurshin; IRID2; IHG2; Rieg Bicoid-Related Homeobox Transcription Factor 1; RIEG Bicoid-Related Homeobox Transcription Factor; Paired-Like Homeodomain 2; All1-Responsive Gene 1; ASGD4; IGDS2; IDG2; PTX2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PITX2 |
| Gene Full Name | Paired Like Homeodomain 2 |
| Background | This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
| Function | May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. [UniProt] |
| Cellular Localization | Cytoplasm; Nucleus. [UniProt] |
| Calculated MW | 35 kDa |
| PTM | Phosphorylated. [UniProt] |
Images (4) Click the Picture to Zoom In
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ARG46725 anti-PITX2 / RGS antibody FACS image
Flow Cytometry: 293T stained with ARG46725 anti-PITX2 / RGS antibody.
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ARG46725 anti-PITX2 / RGS antibody WB image
Western blot: U-87MG stained with ARG46725 anti-PITX2 / RGS antibody.
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ARG46725 anti-PITX2 / RGS antibody WB image
Western blot: Rat heart stained with ARG46725 anti-PITX2 / RGS antibody.
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ARG46725 anti-PITX2 / RGS antibody WB image
Western blot: RAW246.7 stained with ARG46725 anti-PITX2 / RGS antibody.
