anti-PRDM1 / Blimp 1 antibody

anti-PRDM1 / Blimp 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse

Gene Regulation antibody; Immune System antibody
publication_link Publication1


Product Description Rabbit Polyclonal antibody recognizes PRDM1 / Blimp 1
Tested Reactivity Hu, Ms
Predict Reactivity Rat
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name PRDM1 / Blimp 1
Antigen Species Human
Immunogen Synthetic peptide (17 aa) within aa. 100-150 of Human PRDM1 / Blimp1.
Conjugation Un-conjugated
Alternate Names Beta-interferon gene positive regulatory domain I-binding factor; PR domain zinc finger protein 1; BLIMP-1; BLIMP1; PRDI-binding factor 1; PR domain-containing protein 1; EC 2.1.1.-; PRDI-BF1; Positive regulatory domain I-binding factor 1

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P5 μg/ml
WB0.5 - 1 μg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Mouse Lung Tissue Lysate


Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS and 0.02% Sodium azide
Preservative 0.02% Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 12142 Mouse PRDM1

GeneID: 639 Human PRDM1

Swiss-port # O75626 Human PR domain zinc finger protein 1

Swiss-port # Q60636 Mouse PR domain zinc finger protein 1

Gene Symbol PRDM1
Gene Full Name PR domain containing 1, with ZNF domain
Background This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
Function Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. [UniProt]
Research Area Gene Regulation antibody; Immune System antibody
Calculated MW 92 kDa
PTM Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation.
Ubiquitinated by the SCF(FBXO11) complex, leading to its degradation by the proteasome.

Images (2) Click the Picture to Zoom In

  • ARG55270 anti-PRDM1 / Blimp 1 antibody IHC-P image

    Immunohistochemistry: Mouse lung tissue stained with ARG55270 anti-PRDM1 / Blimp 1 antibody at 5 µg/ml dilution.

  • ARG55270 anti-PRDM1 / Blimp 1 antibody WB image

    Western blot: Mouse lung tissue lysate stained with ARG55270 anti-PRDM1 / Blimp 1 antibody.

Specific References

Analysis of Blimp-1 and PD-1/PD-L1 Immune Checkpoint in an Autoimmune Thyroiditis Animal Model.

WB, IHC-P / Mouse

Zhang Xue et al.
International Journal of Endocrinology.,  (2020)