ARG10089

anti-Protein C antibody [HLW-C]

anti-Protein C antibody [HLW-C] for ELISA and Human

Cell Biology and Cellular Response antibody

Overview

Product Description Mouse Monoclonal antibody [HLW-C] recognizes Protein C
Tested Reactivity Hu
Tested Application ELISA
Host Mouse
Clonality Monoclonal
Clone HLW-C
Isotype IgG2b,k
Target Name Protein C
Antigen Species Human
Immunogen Purified human Protein C derived from human blood
Conjugation Un-conjugated
Full Name protein C (inactivator of coagulation factors Va and VIIIa)
Alternate Names EC 3.4.21.69; Blood coagulation factor XIV; PC; THPH3; Vitamin K-dependent protein C; THPH4; APC; Autoprothrombin IIA; PROC1; Anticoagulant protein C

Application Instructions

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Protein G affinity purified
Buffer 0.01M PBS (pH 7.2)
Concentration 1 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 5624 Human PROC

Swiss-port # P04070 Human Vitamin K-dependent protein C

Gene Symbol PROC
Gene Full Name protein C (inactivator of coagulation factors Va and VIIIa)
Background Protein C is a vitamin K dependant glycoprotein in blood. Activated Protein C (APC) functions as an anti-coagulation factor in blood by proteolyzing pro-coagulation factors including Factor V and Factor VIII. When bound with endothelial protein C receptor (EPCR) on vascular endothelial cells, APC acts on protease activated receptor I (PAR-1) to up-regulate the expression of genes involved with anti-inflammatory and anti- apoptotic pathways, thus it also possesses a cell protective function. Protein C is activated by binding with thrombin. The activation is enhanced by thrombomodulin and EPCR.
Function Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. [UniProt]
Research Area Cell Biology and Cellular Response antibody
PTM The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.