ARG46415
anti-Quiescin Q6 antibody
anti-Quiescin Q6 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Quiescin Q6 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Quiescin Q6 |
| Antigen Species | Human |
| Immunogen | A 17 amino acid synthetic peptide within the last 50 amino acids of human Quiescin Q6. |
| Conjugation | Un-conjugated |
| Alternate Names | QSOX1; Quiescin Q6 sulfhydryl oxidase 1; Sulfhydryl oxidase 1; Q6; QSCN6 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 66 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -465°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | QSOX1 |
| Gene Full Name | quiescin Q6 sulfhydryl oxidase 1 |
| Background | This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:23867277, PubMed:30367560). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:22801504, PubMed:23867277, PubMed:30367560). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:23867277, PubMed:30367560). [UniProt] |
| Cellular Localization | Secreted; Golgi apparatus. [UniProt] |
| Calculated MW | 65, 82 kDa |
| PTM | Phosphoprotein; Disulfide bond; Glycoprotein. [UniProt] |
