ARG46795
anti-RAB1B antibody
anti-RAB1B antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Overview
| Product Description | Goat Polyclonal antibody recognizes RAB1B |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RAB1B |
| Immunogen | Purified recombinant peptide derived from within residues 110 aa to the C-terminus of RAB1B produced in E. coli. |
| Conjugation | Un-conjugated |
| Alternate Names | Ras-Related Protein Rab-1B; Small GTP-Binding Protein; Small Monomeric GTPase |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Epitope affinity purified |
| Buffer | PBS, 20% Glycerol and 0.05% Sodium Azide |
| Preservative | 0.05% Sodium Azide |
| Stabilizer | 20% Glycerol |
| Concentration | 3 mg/ml |
| Storage Instruction | For continuous use, store at 2-8 C for one-two days. For extended storage, store in -20 C freezer. Working dilution samples should be discarded if not used within 12 hours. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | RAB1B |
| Gene Full Name | RAB1, member RAS oncogene family |
| Background | Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]). [supplied by OMIM, Jan 2009] |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Required to modulate the compacted morphology of the Golgi. Plays a role in the initial events of autophagic vacuole development, which take place at specialized regions of the endoplasmic reticulum. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment. [UniProt] |
| Cellular Localization | Cytoplasm; Membrane; Preautophagosomal structure. [UniProt] |
| Calculated MW | 22.2 kDa |
| PTM | Acetylation; Glycoprotein; Lipoprotein; Methylation; Phosphoprotein; Prenylation. [UniProt] |
Images (3) Click the Picture to Zoom In
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ARG46795 anti-RAB1B antibody IHC-P image
Immunohistochemistry: Human muscle stained with ARG46795 anti-RAB1B antibody.
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ARG46795 anti-RAB1B antibody WB image
Western blot: Hela stained with ARG46795 anti-RAB1B antibody.
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ARG46795 anti-RAB1B antibody IHC-P image
Immunohistochemistry: Mouse intestine stained with ARG46795 anti-RAB1B antibody.
