ARG46785
anti-RAB25 antibody
anti-RAB25 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Goat Polyclonal antibody recognizes RAB25 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RAB25 |
| Antigen Species | Mouse |
| Immunogen | Purified recombinant peptide derived from within residues 120 aa to the C-terminus of mouse RAB25 produced in E. coli. |
| Conjugation | Un-conjugated |
| Alternate Names | RAB11C; CATX-8; CATX8 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Epitope affinity purified |
| Buffer | PBS, 20% Glycerol and 0.05% Sodium Azide |
| Preservative | 0.05% Sodium Azide |
| Stabilizer | 20% Glycerol |
| Concentration | 2 mg/ml |
| Storage Instruction | For continuous use, store at 2-8 C for one-two days. For extended storage, store in -20 C freezer. Working dilution samples should be discarded if not used within 12 hours. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | RAB25 |
| Gene Full Name | RAB25, member RAS oncogene family |
| Background | The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015] |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. RAB25 regulates epithelial cell differentiation, proliferation and survival. Promotes invasive migration of cells by localizing and maintaining integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions. May selectively regulate the apical recycling pathway; together with MYO5B regulates transcytosis. [UniProt] |
| Cellular Localization | Cell membrane; Cell projection; Cytoplasm; Cytoplasmic vesicle; Endosome; Membrane. [UniProt] |
| Calculated MW | 23.5 kDa |
| PTM | Lipoprotein; Methylation; Prenylation. [UniProt] |
Images (4) Click the Picture to Zoom In
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ARG46785 anti-RAB25 antibody WB image
Western blot: Human breast stained with ARG46785 anti-RAB25 antibody.
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ARG46785 anti-RAB25 antibody IHC-P image
Immunohistochemistry: Rat brain stained with ARG46785 anti-RAB25 antibody.
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ARG46785 anti-RAB25 antibody IHC-P image
Immunohistochemistry: Mouse kidney stained with ARG46785 anti-RAB25 antibody.
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ARG46785 anti-RAB25 antibody IHC-P image
Immunohistochemistry: Mouse intestine stained with ARG46785 anti-RAB25 antibody.
