ARG47256
anti-RAB3GAP1 antibody
anti-RAB3GAP1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes RAB3GAP1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | RAB3GAP1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human RAB3GAP1. |
| Conjugation | Un-conjugated |
| Alternate Names | RAB3GAP1; Rab3 GTPase-activating protein catalytic subunit; KIAA0066; RAB3GAP; RAB3 GTPase-activating protein 130 kDa subunit; Rab3-GAP p130; Rab3-GAP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A |
| Buffer | PBS, 0.09% Sodium azide, 50% Glycerol and 0.5% BSA |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q15042 Human Rab3 GTPase-activating protein catalytic subunit |
|---|---|
| Gene Symbol | RAB3GAP1 |
| Gene Full Name | RAB3 GTPase activating protein catalytic subunit 1 |
| Background | This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] |
| Function | Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which accelerates the otherwise slow GTP hydrolysis catalyzed by Rab proteins. [UniProt] |
| Cellular Localization | Cytoplasm; Golgi apparatus. [UniProt] |
| Calculated MW | 111 kDa |
| PTM | Phosphoprotein. [UniProt] |
