ARG45520
anti-RALB antibody
anti-RALB antibody for Flow cytometry,ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes RALB |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RALB |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to C-terminal region of human RALB. |
| Conjugation | Un-conjugated |
| Alternate Names | RALB; v-ral simian leukemia viral oncogene homolog B; Ras-related protein Ral-B |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 23 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | RALB |
| Gene Full Name | v-ral simian leukemia viral oncogene homolog B |
| Background | This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008] |
| Function | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis. [UniProt] |
| Cellular Localization | Cell membrane. [UniProt] |
| Calculated MW | 23 kDa |
| PTM | Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs). The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of geranylgeranyltransferase I inhibitors, including GGTI-2417.. [UniProt] |
Images (5) Click the Picture to Zoom In
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ARG45520 anti-RALB antibody ICC/IF image
Immunofluorescence: A549 stained with ARG45520 anti-RALB antibody at 5 μg/ml dilution.
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ARG45520 anti-RALB antibody WB image
Western blot: Hela stained with ARG45520 anti-RALB antibody at 0.5 μg/ml dilution.
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ARG45520 anti-RALB antibody FACS image
Flow Cytometry: Jurkat stained with ARG45520 anti-RALB antibody at 1 µg/10^6 cells dilution.
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ARG45520 anti-RALB antibody WB image
Western blot: Rat Brain stained with ARG45520 anti-RALB antibody at 0.5 μg/ml dilution.
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ARG45520 anti-RALB antibody WB image
Western blot: Mouse Spleen stained with ARG45520 anti-RALB antibody at 0.5 μg/ml dilution.
