ARG46417
anti-RAP1 / RABGEF1 antibody
anti-RAP1 / RABGEF1 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes RAP1 / RABGEF1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RAP1 / RABGEF1 |
| Antigen Species | Human |
| Immunogen | A 19 amino acid synthetic peptide within the last 50 amino acids of human RAP1 / RABGEF1. |
| Conjugation | Un-conjugated |
| Alternate Names | RAB guanine nucleotide exchange factor (GEF) 1; RABEX5; RAP1; RABEX5; rabex-5; RAP1; RABGEF1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -467°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | RABGEF1 |
| Gene Full Name | RAB guanine nucleotide exchange factor (GEF) 1 |
| Background | RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010] |
| Function | Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). [UniProt] |
| Cellular Localization | Cytoplasm; Endosome. [UniProt] |
| Calculated MW | 57 kDa |
| PTM | Phosphoprotein; Ubl conjugation. [UniProt] |
