ARG45191
anti-RGS6 antibody
anti-RGS6 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes RGS6 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RGS6 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human RGS6. |
| Conjugation | Un-conjugated |
| Alternate Names | RGS6; Regulator Of G Protein Signaling 6; Regulator Of G-Protein Signaling 6; Regulator Of G-Protein Signalling 6; S914;HA117; GAP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 54 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.01% Sodium azide and 4% Trehalose. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P49758 Human Regulator of G-protein signaling 6 Swiss-port # Q9Z2H2 Mouse Regulator of G-protein signaling 6 |
|---|---|
| Gene Symbol | RGS6 |
| Gene Full Name | Regulator Of G Protein Signaling 6 |
| Background | This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011] |
| Function | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity. [UniProt] |
| Cellular Localization | Cell membrane; Cytoplasm; Membrane; Nucleus [UniProt] |
| Calculated MW | 54 kDa |
Images (5) Click the Picture to Zoom In
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ARG45191 anti-RGS6 antibody IHC-P image
Immunohistochemistry: Human bladder cancer stained with ARG45191 anti-RGS6 antibody at 2 μg/ml dilution.
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ARG45191 anti-RGS6 antibody WB image
Western blot: T47D, MCF-7, and Hela stained with ARG45191 anti-RGS6 antibody at 0.5 μg/ml dilution.
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ARG45191 anti-RGS6 antibody FACS image
Flow Cytometry: MCF-7 stained with ARG45191 anti-RGS6 antibody at 1 µg/10^6 cells dilution.
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ARG45191 anti-RGS6 antibody WB image
Western blot: Rat heart stained with ARG45191 anti-RGS6 antibody at 0.5 μg/ml dilution.
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ARG45191 anti-RGS6 antibody WB image
Western blot: Mouse kidney stained with ARG45191 anti-RGS6 antibody at 0.5 μg/ml dilution.
