ARG46449
anti-RUSC1 antibody
anti-RUSC1 antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes RUSC1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RUSC1 |
| Antigen Species | Human |
| Immunogen | A 17 amino acid synthetic peptide within the last 50 amino acids of human RUSC1. |
| Conjugation | Un-conjugated |
| Alternate Names | RUN and SH3 domain containing 1; RUSC1; NESCA; NESCA; RUN and SH3 domain-containing protein 1; New molecule containing SH3 at the carboxy-terminus; Nesca |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -499°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8BG26 Mouse RUN and SH3 domain-containing protein 1 Swiss-port # Q9BVN2 Human RUN and SH3 domain-containing protein 1 |
|---|---|
| Gene Symbol | RUSC1 |
| Gene Full Name | RUN and SH3 domain containing 1 |
| Background | Predicted to enable actin binding activity. Involved in protein polyubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025] |
| Function | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network (PubMed:30262884). Signaling adapter which plays a role in neuronal differentiation (PubMed:15024033). Involved in regulation of NGF-dependent neurite outgrowth (PubMed:15024033). May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (By similarity). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK (PubMed:15024033). Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway (PubMed:19365808). [UniProt] |
| Cellular Localization | Cytoplasm; Nucleus; Endosome; Cytoplasmic vesicle; Cytoplasmic vesicle; Golgi apparatus. [UniProt] |
| Calculated MW | 96 kDa |
| PTM | Phosphoprotein; Ubl conjugation. [UniProt] |
