ARG67296
anti-Ryanodine receptor 2 / RYR-2 phospho (Ser2808) antibody
anti-Ryanodine receptor 2 / RYR-2 phospho (Ser2808) antibody for Western blot and Human,Mouse,Rabbit,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Ryanodine receptor 2 / RYR-2 phospho (Ser2808) |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Rb |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target Name | Ryanodine receptor 2 / RYR-2 |
| Immunogen | KLH-conjugated phospho-peptide |
| Conjugation | Un-conjugated |
| Alternate Names | Ryanodine receptor 2; RYR-2; RyR2; hRYR-2; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Observed Size | 565 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | 0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 30 % Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | RYR2 |
| Gene Full Name | Ryanodine Receptor 2 |
| Background | This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008] |
| Function | Cytosolic calcium-activated calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. [UniProt] |
| Cellular Localization | Sarcoplasmic reticulum membrane. [UniProt] |
| Calculated MW | 565 kDa |
| PTM | Phosphoprotein. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG67296 anti-Ryanodine receptor 2 / RYR-2 phospho (Ser2808) antibody WB image
Western blot: U251 stained with ARG67296 anti-Ryanodine receptor 2 / RYR-2 phospho (Ser2808) antibody.
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ARG67296 anti-Ryanodine receptor 2 / RYR-2 phospho (Ser2808) antibody WB image
Western blot: Mouse muscle stained with ARG67296 anti-Ryanodine receptor 2 / RYR-2 phospho (Ser2808) antibody.
