ARG10440

anti-S100 antibody [8B10]

anti-S100 antibody [8B10] for Enzyme immunoassay,ELISA,Western blot and Human

Controls and Markers antibody; Neuroscience antibody; Signaling Transduction antibody

Overview

Product Description Mouse Monoclonal antibody [8B10] recognizes S100
Tested Reactivity Hu
Tested Application EIA, ELISA, WB
Host Mouse
Clonality Monoclonal
Clone 8B10
Isotype IgG1
Target Name S100
Antigen Species Human
Immunogen human brain S-100 protein
Conjugation Un-conjugated
Full Name S100 calcium binding protein A1
Alternate Names S-100 protein subunit alpha; S100 calcium-binding protein A1; S-100 protein alpha chain; S100-alpha; S100; Protein S100-A1; S100A

Application Instructions

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Protein A affinity purified.
Buffer PBS (pH 7.4) and 0.1% Sodium azide
Preservative 0.1% Sodium azide
Concentration 1.0-2.0 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 6271 Human S100A1

Swiss-port # P23297 Human Protein S100-A1

Gene Symbol S100A1
Gene Full Name S100 calcium binding protein A1
Background The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
Function Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. [UniProt]
Research Area Controls and Markers antibody; Neuroscience antibody; Signaling Transduction antibody

Clone References

Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS.

IHC-Wmt / Guinea pig

Dai M et al.
Am J Physiol Heart Circ Physiol.,  (2011)

publication_link

 

hr_line

A new long term in vitro model of myelination.

ICC/IF / Rat

Callizot N et al.
Exp Cell Res.,  (2011)

publication_link

 

hr_line

Fibro-vascular coupling in the control of cochlear blood flow.

IHC / Guinea pig

Dai M et al.
PLoS One.,  (2011)

publication_link

 

hr_line

Interaction of developmental transcription factor HOXC11 with steroid receptor coactivator SRC-1 mediates resistance to endocrine therapy in breast cancer [corrected].

WB / Human

McIlroy M et al.
Cancer Res.,  (2010)

publication_link

 

hr_line