ARG10589

anti-S100 antibody [D28-E]

anti-S100 antibody [D28-E] for IHC-Formalin-fixed paraffin-embedded sections and Human

Overview

Product Description Rabbit Monoclonal antibody [D28-E] recognizes S100
Tested Reactivity Hu
Tested Application IHC-P
Host Rabbit
Clonality Monoclonal
Clone D28-E
Isotype IgG
Target Name S100
Antigen Species Human
Immunogen Synthetic peptide around the C-terminus of Human S100-A1 protein
Conjugation Un-conjugated
Full Name S100 calcium binding protein A1
Alternate Names S-100 protein subunit alpha; S100 calcium-binding protein A1; S-100 protein alpha chain; S100-alpha; S100; Protein S100-A1; S100A

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:100 - 1:200
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer 20 mM Tris-HCl (pH 8.0), 0.05% Sodium azide and 20 mg/ml BSA
Preservative 0.05% Sodium azide
Stabilizer 20 mg/ml BSA
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 6271 Human S100A1

Swiss-port # P23297 Human Protein S100-A1

Gene Symbol S100A1
Gene Full Name S100 calcium binding protein A1
Background The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
Function Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. [UniProt]

Images (1) Click the Picture to Zoom In

  • ARG10589 anti-S100 antibody [D28-E] IHC-P image

    Immunohistochemistry: Formalin fixed, paraffin embedded Human cutaneous malignant melanoma (4 µm section) stained with ARG10589 anti-S100 antibody [D28-E].