ARG45262
anti-SAV1 antibody
anti-SAV1 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Polyclonal antibody recognizes SAV1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SAV1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human SAV1. |
| Conjugation | Un-conjugated |
| Alternate Names | SAV1; Salvador Family WW Domain Containing Protein 1; WW45; WWP4; WW Domain-Containing Adaptor 45; Protein Salvador Homolog 1; 45 KDa WW Domain Protein; Salvador; HWW45; Salvador Homolog 1 (Drosophila); Salvador Homolog 1; 1700040G09Rik; SAV |
Application Instructions
| Application Suggestion |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 45 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SAV1 |
| Gene Full Name | Salvador Family WW Domain Containing Protein 1 |
| Background | WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012] |
| Function | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. [UniProt] |
| Cellular Localization | Cytoplasm; Nucleus. [UniProt] |
| Calculated MW | 45 kDa |
| PTM | Phosphoprotein. [UniProt] |
Images (3) Click the Picture to Zoom In
-
ARG45262 anti-SAV1 antibody IHC-P image
Immunohistochemistry: Human spleen stained with ARG45262 anti-SAV1 antibody at 2 μg/ml dilution.
-
ARG45262 anti-SAV1 antibody WB image
Western blot: DLD-1 and 293T stained with ARG45262 anti-SAV1 antibody at 0.5 μg/ml dilution.
-
ARG45262 anti-SAV1 antibody FACS image
Flow Cytometry: U87 stained with ARG45262 anti-SAV1 antibody at 1 µg/10^6 cells dilution.
