ARG45641
anti-SELT antibody
anti-SELT antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SELT |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SELT |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human SELT. |
| Conjugation | Un-conjugated |
| Alternate Names | SELENOT; Selenoprotein T; SELT; Thioredoxin Reductase-Like Selenoprotein T; Thioredoxin Reductase-Like Enzyme; EC 1.8.1.9; SelT |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 22 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SELENOT |
| Gene Full Name | Selenoprotein T |
| Background | This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5. [provided by RefSeq, Sep 2017] |
| Function | Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death. [UniProt] |
| Cellular Localization | Endoplasmic reticulum; Membrane. [UniProt] |
| Calculated MW | 22 kDa |
Images (7) Click the Picture to Zoom In
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ARG45641 anti-SELT antibody IHC-P image
Immunohistochemistry: Human lung adenocarcinoma stained with ARG45641 anti-SELT antibody at 2 μg/ml dilution.
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ARG45641 anti-SELT antibody WB image
Western blot: RT4 stained with ARG45641 anti-SELT antibody at 0.5 μg/ml dilution.
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ARG45641 anti-SELT antibody FACS image
Flow Cytometry: HL-60 stained with ARG45641 anti-SELT antibody at 1 µg/10^6 cells dilution.
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ARG45641 anti-SELT antibody IHC-P image
Immunohistochemistry: Rat kidney stained with ARG45641 anti-SELT antibody at 2 μg/ml dilution.
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ARG45641 anti-SELT antibody WB image
Western blot: Rat pancreas stained with ARG45641 anti-SELT antibody at 0.5 μg/ml dilution.
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ARG45641 anti-SELT antibody IHC-P image
Immunohistochemistry: Mouse brain stained with ARG45641 anti-SELT antibody at 2 μg/ml dilution.
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ARG45641 anti-SELT antibody WB image
Western blot: Mouse pancreas stained with ARG45641 anti-SELT antibody at 0.5 μg/ml dilution.
