ARG46478
anti-SIK2 antibody
anti-SIK2 antibody for Western blot,ICC/IF and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SIK2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SIK2 |
| Antigen Species | Human |
| Immunogen | A 16 amino acid synthetic peptide within the last 50 amino acids of human SIK2. |
| Conjugation | Un-conjugated |
| Alternate Names | SIK2; SNF1LK2; Serine/threonine-protein kinase SIK2; QIK; LOH11CR1I; Qin-induced kinase; Salt-inducible kinase 2; SIK-2; EC 2.7.11.1; Serine/threonine-protein kinase SNF1-like kinase 2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Purification | Affinity chromatography purified |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8CFH6 Mouse Serine/threonine-protein kinase SIK2 Swiss-port # Q9H0K1 Human Serine/threonine-protein kinase SIK2 |
|---|---|
| Gene Symbol | SIK2 |
| Gene Full Name | salt-inducible kinase 2 |
| Function | Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. [UniProt] |
| Calculated MW | 104 kDa |
| PTM | Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG46478 anti-SIK2 antibody ICC/IF image
Immunofluorescence: SW480 stained with ARG46478 anti-SIK2 antibody.
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ARG46478 anti-SIK2 antibody WB image
Western blot: SW480 stained with ARG46478 anti-SIK2 antibody.
