ARG46828
anti-SPINT2 / HAI-2 antibody
anti-SPINT2 / HAI-2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SPINT2 / HAI-2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SPINT2 / HAI-2 |
| Immunogen | Recombinant protein (or fragment). |
| Conjugation | Un-conjugated |
| Alternate Names | PB; Kop; HAI2; DIAR3; HAI-2; SPINT2; HGF Activator Inhibitor 2 |
Application Instructions
| Observed Size | 34 kDa |
|---|
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen |
| Buffer | PBS, Proclin300 or Sodium azide and 50% Glycerol |
| Preservative | Proclin300 or Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SPINT2 |
| Gene Full Name | Serine Peptidase Inhibitor, Kunitz Type 2 |
| Background | This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Function | Inhibitor of HGFAC. Also inhibits plasmin, and plasma and tissue kallikrein. Inhibits serine protease activity of TMPRSS13. Inhibits serine protease activity of ST14/matriptase and PRSS8/prostasin in vitro. [UniProt] |
| Cellular Localization | Cell membrane; Cytoplasm; Membrane. [UniProt] |
| Calculated MW | 28 kDa |
| PTM | Disulfide bond; Glycoprotein. [UniProt] |
Images (2) Click the Picture to Zoom In
-
ARG46828 anti-SPINT2 / HAI-2 antibody IHC-P image
Immunohistochemistry: Human breast cancer stained with ARG46828 anti-SPINT2 / HAI-2 antibody.
-
ARG46828 anti-SPINT2 / HAI-2 antibody WB image
Western blot: MCF-7 stained with ARG46828 anti-SPINT2 / HAI-2 antibody.
