ARG46522
anti-SPRED3 antibody
anti-SPRED3 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SPRED3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SPRED3 |
| Antigen Species | Human |
| Immunogen | A 16 amino acid synthetic peptide within the last 50 amino acids of human SPRED3. |
| Conjugation | Un-conjugated |
| Alternate Names | sprouty-related, EVH1 domain containing 3; Spred3; Eve-3; spred-3; EVE-3; Sprouty-related; EVH1 domain-containing protein 3; Spred-3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 45 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -572°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q2MJR0 Human Sprouty-related, EVH1 domain-containing protein 3 |
|---|---|
| Gene Symbol | SPRED3 |
| Gene Full Name | sprouty-related, EVH1 domain containing 3 |
| Background | This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
| Function | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). [UniProt] |
| Cellular Localization | Cell membrane. [UniProt] |
| Calculated MW | 45 kDa |
| PTM | Phosphoprotein; Ubl conjugation; Lipoprotein; Palmitate; Methylation. [UniProt] |
