ARG67219
anti-SRY / TDF antibody
anti-SRY / TDF antibody for Western blot and Bovine
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SRY / TDF |
|---|---|
| Tested Reactivity | Bov |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target Name | SRY / TDF |
| Antigen Species | Bovine |
| Immunogen | Recombinant fragment corresponding to aa. M1-Y229 of Bovine SRY / TDF. |
| Conjugation | Un-conjugated |
| Alternate Names | SRY; Sex Determining Region Y; TDF; Sex-Determining Region Y Protein; Testis-Determining Factor; Essential Protein For Sex Determination In Human Males; Testis-Determining Factor On Y; Sex-Determining Region On Y; SRXX1; SRXY1; TDY |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS |
| Concentration | 0.1 - 1.0 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SRY |
| Gene Full Name | Sex Determining Region Y |
| Background | This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008] |
| Function | Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing |
| Cellular Localization | Cytoplasm; Nucleus. [UniProt] |
| Calculated MW | 27 kDa |
| PTM | Acetylation. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG67219 anti-SRY / TDF antibody WB image
Western blot: SRY / TDF recombinant protein stained with ARG67219 anti-SRY / TDF antibody.
