anti-STAT6 antibody [SQab22264]

anti-STAT6 antibody [SQab22264] for IHC-Formalin-fixed paraffin-embedded sections and Human

Gene Regulation antibody; Signaling Transduction antibody


Product Description Recombinant Rabbit Monoclonal antibody [SQab22264] recognizes STAT6
Tested Reactivity Hu
Tested Application IHC-P
Host Rabbit
Clonality Monoclonal
Clone SQab22264
Isotype IgG
Target Name STAT6
Antigen Species Human
Immunogen A synthetic peptide corresponding to the sequence of human Stat6.
Conjugation Un-conjugated
Protein Full Name Signal transducer and activator of transcription 6
Alternate Names D12S1644; STAT6B; STAT6C; Signal transducer and activator of transcription 6; IL-4-STAT; IL-4 Stat

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:100 - 1:200
Application Note IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0). Incubate the samples at RT (18-25°C) for 30 min.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Human solitary fibrous tumor (SFT) tissue


Form Liquid
Purification Purification with Protein A.
Buffer PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA.
Preservative 0.01% Sodium azide
Stabilizer 40% Glycerol and 0.05%BSA
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 6778 Human STAT6

Swiss-port # P42226 Human Signal transducer and activator of transcription 6

Gene Symbol STAT6
Gene Full Name signal transducer and activator of transcription 6, interleukin-4 induced
Background The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Function Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. [UniProt]
Research Area Gene Regulation antibody; Signaling Transduction antibody
Calculated MW 94 kDa
PTM Tyrosine phosphorylated following stimulation by IL4/interleukin-4 and IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.

Images (1) Click the Picture to Zoom In

  • ARG66935 anti-STAT6 antibody [SQab22264] IHC-P image

    Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded sections of Human solitary fibrous tumor (SFT) tissue stained with ARG66935 anti-STAT6 antibody [SQab22264]. Antigen Retrieval: Heat tissue section in Tris-EDTA buffer (pH 9.0).