ARG54106

anti-SWAP70 antibody

anti-SWAP70 antibody for Western blot,Immunoprecipitation and Human,Mouse,Rat,Monkey

Immune System antibody; Signaling Transduction antibody

Overview

Product Description Mouse Monoclonal antibody recognizes SWAP70
Tested Reactivity Hu, Ms, Rat, Mk
Tested Application IP, WB
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Target Name SWAP70
Antigen Species Human
Immunogen Purified recombinant human SWAP70 protein fragments expressed in E.coli.
Conjugation Un-conjugated
Alternate Names SWAP-70; Switch-associated protein 70; HSPC321

Application Instructions

Application Suggestion
Tested Application Dilution
IPAssay-dependent
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size 70 kDa

Properties

Form Liquid
Buffer Ascites
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 20947 Mouse SWAP70

GeneID: 23075 Human SWAP70

Swiss-port # Q6A028 Mouse Switch-associated protein 70

Swiss-port # Q9UH65 Human Switch-associated protein 70

Gene Symbol SWAP70
Gene Full Name SWAP switching B-cell complex 70kDa subunit
Background Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which,_x000D_ independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane_x000D_ ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated_x000D_ phosphatidylinositol (3,4)-bisphosphate production and cell protrusion
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). [UniProt]
Cellular Localization Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium.
Research Area Immune System antibody; Signaling Transduction antibody
Calculated MW 69 kDa
PTM Tyrosine-phosphorylated.

Images (2) Click the Picture to Zoom In

  • ARG54106 anti-SWAP70 antibody WB image

    Western blot: 3T3 cell lysate stained with ARG54106 anti-SWAP70 antibody at 1:1000 dilution.

  • ARG54106 anti-SWAP70 antibody IP image

    Immunoprecipitation: HeLa cell lysates were immunoprecipitated and stained with ARG54106 anti-SWAP70 antibody.