ARG67279
anti-Slow Skeletal Myosin Heavy chain antibody
anti-Slow Skeletal Myosin Heavy chain antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Monoclonal antibody recognizes Slow Skeletal Myosin Heavy chain |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Specificity | The antibody detects endogenous Slow Skeletal Myosin Heavy chain protein. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG,Kappa |
| Target Name | Slow Skeletal Myosin Heavy chain |
| Conjugation | Un-conjugated |
| Alternate Names | MYH7; myosin, heavy chain 7, cardiac muscle, beta; SPMD; MyHC-slow; SPMM; Myosin heavy chain 7; CMD1S; Myosin heavy chain, cardiac muscle beta isoform; MyHC-beta; MPD1; MYHCB; CMH1; Myosin heavy chain slow isoform; Myosin-7 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A |
| Buffer | PBS, 0.05% Proclin 300 , 50% glycerol and 0.05% BSA |
| Preservative | 0.05% Proclin 300 |
| Stabilizer | 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MYH7 |
| Gene Full Name | myosin, heavy chain 7, cardiac muscle, beta |
| Background | Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008] |
| Function | Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis. [UniProt] |
| Cellular Localization | Cytoplasm, myofibril. Thick filaments of the myofibrils. [UniProt] |
| Calculated MW | 223 kDa |
Images (1) Click the Picture to Zoom In
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ARG67279 anti-Slow Skeletal Myosin Heavy chain antibody WB image
Western blot: Various whole cell lysate stained with ARG67279 anti-Slow Skeletal Myosin Heavy chain antibody.
