anti-Synapsin 1 antibody
anti-Synapsin 1 antibody for Western blot and Human,Mouse,Rat
|Product Description||Rabbit Polyclonal antibody recognizes Synapsin 1|
|Tested Reactivity||Hu, Ms, Rat|
|Target Name||Synapsin 1|
|Immunogen||Native protein purified from bovine brain|
|Alternate Names||SYNI; Brain protein 4.1; Synapsin-1; SYN1a; SYN1b; Synapsin I|
|Application Note||Specific for the ~78k synapsin I protein doublet. Immunolabeling blocked by preadsorption of the antibody with the protein used to geneRate the antibody.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
|Storage Instruction||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
|Gene Full Name||synapsin I|
|Background||Synapsin I plays a key role in synaptic plasticity in the brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation (Moore and Bernstein, 1989; Stone et al., 1994). Thus, Synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002).|
|Research Area||Neuroscience antibody|
|Calculated MW||74 kDa|
|PTM||Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.
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