ARG52428

anti-Synapsin 1 antibody

anti-Synapsin 1 antibody for Western blot and Human,Mouse,Rat

Neuroscience antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes Synapsin 1
Tested Reactivity Hu, Ms, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Synapsin 1
Antigen Species Bovine
Immunogen Native protein purified from bovine brain
Conjugation Un-conjugated
Alternate Names SYNI; Brain protein 4.1; Synapsin-1; SYN1a; SYN1b; Synapsin I

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000
Application Note Specific for the ~78k synapsin I protein doublet. Immunolabeling blocked by preadsorption of the antibody with the protein used to geneRate the antibody.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Neat Serum
Buffer Neat serum
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 20964 Mouse SYN1

GeneID: 24949 Rat SYN1

GeneID: 6853 Human SYN1

Gene Symbol SYN1
Gene Full Name synapsin I
Background Synapsin I plays a key role in synaptic plasticity in the brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation (Moore and Bernstein, 1989; Stone et al., 1994). Thus, Synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002).
Research Area Neuroscience antibody
Calculated MW 74 kDa
PTM Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.

Images (1) Click the Picture to Zoom In

  • ARG52428 anti-Synapsin 1 antibody WB image

    Western blot: Rat hippocampal (Hipp) lysate stained with ARG52428 anti-Synapsin 1 antibody showing specific immunolabeling of the ~78k synapsin I doublet protein.