anti-Synapsin 1 phospho (Ser9) antibody

anti-Synapsin 1 phospho (Ser9) antibody for ICC/IF,IHC-Frozen sections,Western blot and Human,Mouse,Rat

Neuroscience antibody
publication_link Publication1


Product Description Rabbit Polyclonal antibody recognizes Synapsin 1 phospho (Ser9)
Tested Reactivity Hu, Ms, Rat
Tested Application ICC/IF, IHC-Fr, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Synapsin 1
Antigen Species Rat
Immunogen Phosphospecific peptide around Ser9 (R-L-S(p)-D-S) of Human Synapsin 1.
Conjugation Un-conjugated
Alternate Names SYNI; Brain protein 4.1; Synapsin-1; SYN1a; SYN1b; Synapsin I

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:100 - 1:200
WB1:500 - 1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Antibodies were produced by immunizing rabbits with KLH-conjugated synthetic phosphopeptide. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. In addition, non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Buffer PBS (without Mg2+ and Ca2+, pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 20964 Mouse SYN1

GeneID: 24949 Rat SYN1

GeneID: 6853 Human SYN1

Gene Symbol SYN1
Gene Full Name synapsin I
Background This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Function Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. [UniProt]
Research Area Neuroscience antibody
Calculated MW 74 kDa
PTM Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.

Images (2) Click the Picture to Zoom In

  • ARG51751 anti-Synapsin 1 phospho (Ser9) antibody ICC/IF image

    Immunofluorescence: Methanol-fixed HeLa cells stained with ARG51751 anti-Synapsin 1 phospho (Ser9) antibody.

  • ARG51751 anti-Synapsin 1 phospho (Ser9) antibody WB image

    Western blot: Extracts from Mouse brain tissue stained with ARG51751 anti-Synapsin 1 phospho (Ser9) antibody.

Specific References

miR-132 regulates the expression of synaptic proteins in APP/PS1 transgenic mice through C1q.

WB, IHC-Fr / Mouse

Xu Nan et al.
Eur J Histochem.,  (2019)