Overview

Product Description	Rabbit Polyclonal antibody recognizes TAB3
Tested Reactivity	Hu
Tested Application	IHC-P
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	TAB3
Antigen Species	Human
Immunogen	A 13 amino acid synthetic peptide within the last 50 amino acids of human TAB3.
Conjugation	Un-conjugated
Alternate Names	TAB3; TAB-3; MAP3K7IP3; NAP1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; NF-kappa-B-activating protein 1; TGF-beta-activated kinase 1-binding protein 3; TAK1-binding protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3

Application Instructions

Application Suggestion	Tested Application Dilution IHC-P Assay-dependent
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Purification	Affinity chromatography purified
Buffer	PBS and 0.02% Sodium azide.
Preservative	0.02% Sodium azide
Concentration	1 mg/ml
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 257397 Human TAB3 Swiss-port # Q8N5C8 Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
Gene Symbol	TAB3
Gene Full Name	TGF-beta activated kinase 1/MAP3K7 binding protein 3
Background	The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Function	Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. [From Uniprot]
Calculated MW	79 kDa
PTM	Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment.

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