ARG54729

anti-TAB3 antibody

anti-TAB3 antibody for Western blot and Human

Gene Regulation antibody; Immune System antibody; Signaling Transduction antibody

Overview

Product Description

Rabbit Polyclonal antibody recognizes TAB3

Tested Reactivity Hu
Predict Reactivity Ms
Tested Application WB
Host Rabbit
Clonality Polyclonal
Target Name TAB3
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 1-30 (N-terminus) of Human TAB3 (NP_690000.3).
Conjugation Un-conjugated
Alternate Names TAB-3; MAP3K7IP3; NAP1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; NF-kappa-B-activating protein 1; TGF-beta-activated kinase 1-binding protein 3; TAK1-binding protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Purification Protein A purified
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 257397 Human TAB3

Swiss-port # Q8N5C8 Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Gene Symbol TAB3
Gene Full Name TGF-beta activated kinase 1/MAP3K7 binding protein 3
Background The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Function Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. [From Uniprot]
Highlight Related products:
Anti-Rabbit IgG secondary antibodies;
Related poster download:
The NF-kappa B Pathways.pdf
Research Area Gene Regulation antibody; Immune System antibody; Signaling Transduction antibody
Calculated MW 79 kDa
PTM Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.
Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment.

Images (1) Click the Picture to Zoom In

  • ARG54729 anti-TAB3 antibody WB image

    Western blot: 30 µg of 1) HeLa without treatment, 2-4) HeLa treated with 5 ng/ml TNF-a for 5, 10 and 20 min, respectively. Cell lysates stained with ARG54729 anti-TAB3 antibody at 1:500 dilution.