ARG54030

anti-TBLR1 antibody

anti-TBLR1 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF and Human,Mouse

Cancer antibody; Gene Regulation antibody; Metabolism antibody

Overview

Product Description Mouse Monoclonal antibody recognizes TBL1XR1
Tested Reactivity Hu, Ms
Tested Application ICC/IF, IHC-P, WB
Host Mouse
Clonality Monoclonal
Isotype IgG1
Target Name TBLR1
Antigen Species Human
Immunogen Purified recombinant human TBLR1 protein fragments expressed in E.coli.
Conjugation Un-conjugated
Alternate Names C21; TBLR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; F-box-like/WD repeat-containing protein TBL1XR1; Transducin beta-like 1X-related protein 1; TBL1-related protein 1; IRA1; DC42

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:200
IHC-PAssay-dependent
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size 60 kDa

Properties

Form Liquid
Purification Affinity purified
Buffer 0.1M Tris-Glycine (pH 7.4), 150 mM NaCl, 0.2% Sodium azide and 50% Glycerol
Preservative 0.2% Sodium azide
Stabilizer 50% Glycerol
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 79718 Human TBL1XR1

GeneID: 81004 Mouse TBL1XR1

Swiss-port # Q8BHJ5 Mouse F-box-like/WD repeat-containing protein TBL1XR1

Swiss-port # Q9BZK7 Human F-box-like/WD repeat-containing protein TBL1XR1

Gene Symbol TBL1XR1
Gene Full Name transducin (beta)-like 1 X-linked receptor 1
Background F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, th ereby allowing cofactor exchange, and transcription activation.
Function F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. [UniProt]
Cellular Localization Nucleus
Research Area Cancer antibody; Gene Regulation antibody; Metabolism antibody
Calculated MW 56 kDa

Images (3) Click the Picture to Zoom In

  • ARG54030 anti-TBLR1 antibody ICC/IF image

    Immunofluorescence: HeLa cells fixed with 4% Paraformaldehyde and stained with ARG54030 anti-TBLR1 antibody at 1:200 dilution.

  • ARG54030 anti-TBLR1 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human breast cancer tissue stained with ARG54030 anti-TBLR1 antibody at 1:500 - 1:1000 dilution.

  • ARG54030 anti-TBLR1 antibody WB image

    Western blot: K562 cell lysate stained with ARG54030 anti-TBLR1 antibody at 1:1000 dilution.