anti-TFAM antibody for Western blot and Human,Mouse,Rat
Cell Biology and Cellular Response antibody; Controls and Markers antibody; Gene Regulation antibody; Metabolism antibody; Signaling Transduction antibody
|Product Description||Rabbit Polyclonal antibody recognizes TFAM|
|Tested Reactivity||Hu, Ms, Rat|
|Immunogen||Native recombinant mouse TFAM protein with c-terminal 6-his tag|
|Alternate Names||TCF6; MTTFA; mtTFA; TCF-6; Transcription factor A, mitochondrial; MtTF1; MTTF1; Mitochondrial transcription factor 1; Transcription factor 6-like 2; TCF6L1; Transcription factor 6; TCF6L3; TCF6L2|
|Application Note||Specific for the ~24 kDa TFAM protein.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
|Storage Instruction||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
|Gene Full Name||transcription factor A, mitochondrial|
|Background||Mitochondrial Transcription Factor A (TFAM) is a key activator of mitochondrial (mt) DNA transcription as well as a participant in mitochondrial genome replication. mtDNA is highly susceptible to oxidative stress leading to mitochondrial dysfunction. Overexpression of TFAM has been implicated in the amelioration of age dependent impairment of brain functions through the prevention of oxidative stress and mitochondrial dysfunction in microglia (Hayashi et al., 2008). More recently, TFAM overexpression has been shown to potentially reduce oxidative stress in motor neurons and delay onset of amyotrophic lateral sclerosis (ALS) in ALS model mice (Morimoto et al., 2012).|
|Research Area||Cell Biology and Cellular Response antibody; Controls and Markers antibody; Gene Regulation antibody; Metabolism antibody; Signaling Transduction antibody|
|Calculated MW||29 kDa|
|PTM||Phosphorylation by PKA within the HMG box 1 impairs DNA binding and promotes degradation by the AAA+ Lon protease.|
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