anti-TGFBR2 / TGF beta Receptor II antibody

anti-TGFBR2 / TGF beta Receptor II antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat

publication_link Publication4


Product Description Rabbit Polyclonal antibody recognizes TGFBR2 / TGF beta Receptor II
Tested Reactivity Hu, Ms, Rat
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name TGFBR2 / TGF beta Receptor II
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 23-280 of Human TGFBR2 / TGF beta Receptor II (NP_003233.4).
Conjugation Un-conjugated
Alternate Names FAA3; AAT3; TbetaR-II; TGF-beta receptor type-2; LDS2B; MFS2; TGF-beta type II receptor; EC; TAAD2; TGFR-2; LDS2; Transforming growth factor-beta receptor type II; TGFbeta-RII; TGF-beta receptor type II; RIIC; LDS1B

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:200
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Rat lung, Mouse lung and A549
Observed Size 75 kDa


Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 21813 Mouse TGFBR2

GeneID: 7048 Human TGFBR2

GeneID: 81810 Rat TGFBR2

Gene Symbol TGFBR2
Gene Full Name transforming growth factor, beta receptor II (70/80kDa)
Background This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. [UniProt]
Cellular Localization Cell membrane; Single-pass type I membrane protein. Membrane raft. [UniProt]
Calculated MW 65 kDa
PTM Phosphorylated on a Ser/Thr residue in the cytoplasmic domain. [UniProt]

Images (3) Click the Picture to Zoom In

  • ARG59501 anti-TGFBR2 / TGF beta Receptor II antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human appendix stained with ARG59501 anti-TGFBR2 / TGF beta Receptor II antibody at 1:100 dilution.

  • ARG59501 anti-TGFBR2 / TGF beta Receptor II antibody WB image

    Western blot: 25 µg of Rat lung, Mouse lung and A549 cell lysates stained with ARG59501 anti-TGFBR2 / TGF beta Receptor II antibody at 1:1000 dilution.

  • ARG59501 anti-TGFBR2 / TGF beta Receptor II antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human breast cancer stained with ARG59501 anti-TGFBR2 / TGF beta Receptor II antibody at 1:100 dilution.

Specific References

Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway

WB / Mouse

Fei Geng et al.
Curr. Issues Mol. Biol,  (2023)




OC-STAMP Overexpression Drives Lung Alveolar Epithelial Cell Type II Senescence in Silicosis

WB / Rat

Tian Li et al.
Oxid Med Cell Longev.,  (2021)




Differential expression of lncRNAs during silicosis and the role of LOC103691771 in myofibroblast differentiation induced by TGF-β1.

WB / Rat

Cai Wenchen et al.
Biomedicine & Pharmacotherapy.,  (2020)




MiR-411-3p alleviates Silica-induced pulmonary fibrosis by regulating Smurf2/TGF-β signaling.

WB, IHC-P / Mouse

Gao Xuemin et al.
Exp Cell Res.,  (2020)