ARG46569
anti-TICAM2 antibody
anti-TICAM2 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TICAM2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TICAM2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide near the C-terminus of human TICAM2. |
| Conjugation | Un-conjugated |
| Alternate Names | TICAM2; toll-like receptor adaptor molecule 2; TIRP; TIRP; TRAM; TIRAP3; MyD88-4; TICAM-2; TIRP; TIR domain-containing adapter molecule 2; Putative NF-kappa-B-activating protein 502 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Ion exchange chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -619°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q86XR7 Human TIR domain-containing adapter molecule 2 Swiss-port # Q8BJQ4 Mouse TIR domain-containing adapter molecule 2 |
|---|---|
| Gene Symbol | TICAM2 |
| Gene Full Name | toll-like receptor adaptor molecule 2 |
| Background | Enables molecular adaptor activity. Involved in several processes, including positive regulation of interleukin-18-mediated signaling pathway; regulation of cytokine production; and regulation of innate immune response. Located in endoplasmic reticulum; endosome; and phagocytic cup. Is active in endosome membrane. [provided by Alliance of Genome Resources, Jul 2025] |
| Function | Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606). [UniProt] |
| Cellular Localization | Cytoplasm; Cell membrane; Endosome; Cell projection; Golgi apparatus; Cell membrane . [UniProt] |
| Calculated MW | 27 kDa |
| PTM | Phosphoprotein; Lipoprotein; Myristate. [UniProt] |
