ARG46819
anti-TLS / FUS antibody
anti-TLS / FUS antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TLS / FUS |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TLS / FUS |
| Antigen Species | Human |
| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human TLS / FUS, identical to the related mouse sequences. |
| Conjugation | Un-conjugated |
| Alternate Names | TLS; Translocated in liposarcoma protein; ETM4; POMp75; FUS1; ALS6; RNA-binding protein FUS; Oncogene TLS; POMP75; 75 kDa DNA-pairing protein; Oncogene FUS; HNRNPP2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 70 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen |
| Purification Note | 4% Trehalose, 0.9% NaCl, 0.2% Na2HPO4 |
| Buffer | 4% Trehalose |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O75388 Human Probable G-protein coupled receptor 32 |
|---|---|
| Gene Symbol | FUS |
| Gene Full Name | FUS RNA binding protein |
| Background | This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009] |
| Function | Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 53.4 kDa |
| PTM | Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine. [UniProt] |
