ARG58722
anti-TLS / FUS antibody
anti-TLS / FUS antibody for ICC/IF,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TLS / FUS |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TLS / FUS |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 297-526 of Human FUS (NP_004951.1). |
| Conjugation | Un-conjugated |
| Alternate Names | TLS; Translocated in liposarcoma protein; ETM4; POMp75; FUS1; ALS6; RNA-binding protein FUS; Oncogene TLS; POMP75; 75 kDa DNA-pairing protein; Oncogene FUS; HNRNPP2 |
Application Instructions
| Application Suggestion |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | U937 | ||||||||
| Observed Size | 70 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | FUS |
| Gene Full Name | FUS RNA binding protein |
| Background | This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009] |
| Function | Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 53 kDa |
| PTM | Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine. [UniProt] |
Images (1) Click the Picture to Zoom In
-
ARG58722 anti-TLS / FUS antibody WB image
Western blot: 25 µg of U937 cell lysate stained with ARG58722 anti-TLS / FUS antibody at 1:1000 dilution.
