ARG46575
anti-TMEM106A antibody
anti-TMEM106A antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TMEM106A |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TMEM106A |
| Antigen Species | Human |
| Immunogen | A 14 amino acid synthetic peptide within the last 50 amino acids of human TMEM106A. |
| Conjugation | Un-conjugated |
| Alternate Names | TMEM106A; Transmembrane protein 106A |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -625°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | TMEM106A |
| Gene Full Name | transmembrane protein 106A |
| Background | Predicted to be involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule biosynthetic process; and positive regulation of nitric oxide metabolic process. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] |
| Function | Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (PubMed:29131025, PubMed:30456879). [UniProt] |
| Cellular Localization | Cell membrane; Cell membrane . [UniProt] |
| Calculated MW | 29 kDa |
