ARG46606
anti-TRIM30 / Rpt1 antibody
anti-TRIM30 / Rpt1 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TRIM30 / Rpt1 |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TRIM30 / Rpt1 |
| Antigen Species | Mouse |
| Immunogen | A 21 amino acid synthetic peptide within the last 50 amino acids of mouse TRIM30 / Rpt1. |
| Conjugation | Un-conjugated |
| Alternate Names | tripartite motif-containing 30; TRIM30; Rpt1; Rpt-1; Trim30; Rpt1; Tripartite motif-containing protein 30A; Down regulatory protein of interleukin-2 receptor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 105 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -656°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P15533 Mouse Tripartite motif-containing protein 30A |
|---|---|
| Gene Symbol | Trim30 |
| Gene Full Name | tripartite motif-containing 30 |
| Background | Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of cytokine production; protein autoubiquitination; and regulation of pattern recognition receptor signaling pathway. Acts upstream of or within response to bacterium. Located in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; heart; and limb. Orthologous to human TRIM5 (tripartite motif containing 5). [provided by Alliance of Genome Resources, Jul 2025] |
| Function | Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses. [UniProt] |
| Cellular Localization | Cytoplasm; Nucleus. [UniProt] |
| Calculated MW | 107 kDa |
