ARG46747
anti-TRP1 antibody
anti-TRP1 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TRP1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TRP1 |
| Immunogen | Synthetic peptide |
| Conjugation | Un-conjugated |
| Alternate Names | CATB; TYRP; b-PROTEIN; EC 1.14.18.-; CAS2; DHICA oxidase; Melanoma antigen gp75; 5,6-dihydroxyindole-2-carboxylic acid oxidase; Catalase B; OCA3; TRP; GP75; TRP1; Glycoprotein 75; TRP-1; Tyrosinase-related protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 90 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS, 50% Glycerol, Proclin 300 or sodium azide |
| Preservative | Proclin 300 or sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P07147 Mouse 5,6-dihydroxyindole-2-carboxylic acid oxidase Swiss-port # P17643 Human 5,6-dihydroxyindole-2-carboxylic acid oxidase |
|---|---|
| Gene Symbol | TYRP1 |
| Gene Full Name | tyrosinase-related protein 1 |
| Background | This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009] |
| Function | Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. [UniProt] |
| Cellular Localization | Melanosome membrane; Single-pass type I membrane protein. Melanosome. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. [UniProt] |
| Calculated MW | 91 kDa |
| PTM | Glycosylated. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG46747 anti-TRP1 antibody WB image
Western blot: MCF7 stained with ARG46747 anti-TRP1 antibody.
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ARG46747 anti-TRP1 antibody WB image
Western blot: Mouse kidney stained with ARG46747 anti-TRP1 antibody.
