anti-TYK2 phospho (Tyr1054) antibody

anti-TYK2 phospho (Tyr1054) antibody for Western blot and Human,Mouse,Rat

Signaling Transduction antibody
publication_link Publication1


Product Description Rabbit Polyclonal antibody recognizes TYK2 phospho (Tyr1054)
Tested Reactivity Hu, Ms, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name TYK2
Antigen Species Human
Immunogen Peptide sequence around phosphorylation site of tyrosine 1054 (H-E-Y(p)-Y-R) derived from Human TYK2.
Conjugation Un-conjugated
Alternate Names JTK1; IMD35; Non-receptor tyrosine-protein kinase TYK2; EC

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Antibodies were produced by immunizing rabbits with KLH-conjugated synthetic phosphopeptide. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. In addition, non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Buffer PBS (without Mg2+ and Ca2+, pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 7297 Human TYK2

Swiss-port # P29597 Human Non-receptor tyrosine-protein kinase TYK2

Gene Symbol TYK2
Gene Full Name tyrosine kinase 2
Background TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Function Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. [UniProt]
Research Area Signaling Transduction antibody
Calculated MW 134 kDa

Images (1) Click the Picture to Zoom In

  • ARG51647 anti-TYK2 phospho (Tyr1054) antibody WB image

    Western blot: Extracts from HT29 cells untreated(lane 1) or treated with Anisomycin(lane 2) stained with ARG51647 anti-TYK2 phospho (Tyr1054) antibody.

Specific References

Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.

WB / Rat

Zhang Yue-Zhu et al.
Biomed Environ Sci.,  (2019)