anti-Thyroid Hormone Receptor alpha antibody [2103]

anti-Thyroid Hormone Receptor alpha antibody [2103] for Western blot and Human,Rat

Gene Regulation antibody; Neuroscience antibody; Signaling Transduction antibody


Product Description Mouse Monoclonal antibody [2103] recognizes Thyroid Hormone Receptor alpha
Tested Reactivity Hu, Rat
Predict Reactivity Ms, Dog, NHuPrm
Tested Application WB
Host Mouse
Clonality Monoclonal
Clone 2103
Isotype IgG1
Target Name Thyroid Hormone Receptor alpha
Antigen Species Human
Immunogen Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH
Conjugation Un-conjugated
Alternate Names c-ERBA-1; c-erbA-1; Thyroid hormone receptor alpha; V-erbA-related protein 7; AR7; NR1A1; Nuclear receptor subfamily 1 group A member 1; ERBA1; CHNG6; THRA1; THRA2; ERB-T-1; c-erbA-alpha; ERBA; EAR7; EAR-7

Application Instructions

Application Suggestion
Tested Application Dilution
Application Note Specific for the ~50k TR-α1 and the ~58k TR-α2 proteins.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Protein G purified
Buffer 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol
Stabilizer 0.1 mg/ml BSA, 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 7067 Human THRA

GeneID: 81812 Rat THRA

Swiss-port # P10827 Human Thyroid hormone receptor alpha

Swiss-port # P63059 Rat Thyroid hormone receptor alpha

Gene Symbol THRA
Gene Full Name thyroid hormone receptor, alpha
Background Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
Research Area Gene Regulation antibody; Neuroscience antibody; Signaling Transduction antibody
Calculated MW 55 kDa

Images (1) Click the Picture to Zoom In

  • ARG52445 anti-Thyroid Hormone Receptor alpha antibody [2103] WB image

    Western blot: Rat hippocampal lysate showing specific immunolabeling of the ~50 kDa TR-α1 and the ~58 kDa TR-α2 protein stained with ARG52445 anti-Thyroid Hormone Receptor alpha antibody [2103]